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The principal cytochrome P450 isoenzyme associated seems being CYP2E1, with CYP1A2 and CYP3A4 as further pathways. Approximately eighty five% of an oral dose appears while in the urine within just 24 hrs of administration, most because the glucuronide conjugate, with little quantities of other conjugates and unchanged drug [see OVERDOSAGE] for toxi